On a meet.jit.si conference I organized on Saturday from 10:30-2:30 PM EDT, I had one user with Microsoft Edge whose audio sounded like a squirrel was crawing around inside the speakers. She was audible, but it was very annoying. She had to keep herself muted except when speaking.
Window 10 Home, version 1909
Microsoft Edge: Version 84.0.522.52 (64bit)