A colleague of mine came across this behavior:
He started a vpn connection to Avaya after he started JITSI. JITSI did
not recognize the vpn connection and kept trying to REGISTER with the
old IP address and port.
Not sure if you care to address this use case but it might be a fairly
common use case. i.e. You are running a bunch of apps on your PC and
you now vpn to your office. Should the clients continue to work or at
least detect this and prompt the user? Could it be arranged for JITSI
to recognize the presence of a new interface that it can bind to and
put up a popup asking if the user would like to restart it?