Can I configure Jitsi to one to many video room?

Hi friends,

can Jitsi configure that one person have a video other only can watch the stream?

Hi,

sound interesting. So do you mean like a Web-Seminar?

Yes, exactly.

It seems that a streaming solution would fit better your needs. Jitsi Meet is made with conferences in mind.
Still, if you prefer to use Jitsi Meet for this, you can try setting the following in config.js:
startAudioMuted: 1,
startVideoMuted: 1,
channelLastN: 1,
And then be sure the host joins first, so all the attendees will join after him with camera and mic muted. They will have the ability to manually unmute themselves, though.